The Role of Vitamin D, Myo-Inositol, and Melatonin in the Redox-Endocrine Network of PCOS: Exploring Their Potential Synergistic Effects - Summary - MDSpire

The Role of Vitamin D, Myo-Inositol, and Melatonin in the Redox-Endocrine Network of PCOS: Exploring Their Potential Synergistic Effects

  • By

  • Subakathulla, Sumayyah

  • Manoj, Norwin

  • Patanwala, Azima Muzzammil

  • Premvignesh, Prasanna Appiya

  • Maher, Yamen

  • Majie, Ankit

  • Gorain, Bapi

  • Dutta, PhD, Sulagna

  • Sengupta, PhD, Pallav

  • Maldonado Rosas, Israel

  • Roychoudhury, Shubhadeep

  • April 9, 2026

  • 0 min

Share

Objective:

To examine the potential synergistic effects of vitamin D, myo-inositol, and melatonin in addressing the multifaceted issues of PCOS through a redox-endocrine network.

Key Findings:
  • Vitamin D modulates inflammation and steroidogenic signaling.
  • Myo-inositol restores insulin signaling and reduces androgen excess.
  • Melatonin influences mitochondrial function and redox balance.
  • Existing clinical trials show improvements in ovulatory function and insulin resistance, but results are heterogeneous.
Interpretation:

The combined supplementation of vitamin D, myo-inositol, and melatonin may offer a targeted approach to address the underlying mechanisms of PCOS rather than just its symptoms.

Limitations:
  • Heterogeneity in clinical trial outcomes due to variations in dosing, duration, and patient phenotypes.
  • Need for a redox-guided, phenotype-aware framework in future research.
Conclusion:

If validated, a combined nutraceutical strategy targeting the core pathophysiology of PCOS could enhance treatment efficacy.

Original Source(s)

The Role of Vitamin D, Myo-Inositol, and Melatonin in the Redox-Endocrine Network of PCOS: Exploring Their Potential Synergistic Effects

  • by Subakathulla, Sumayyah , Manoj, Norwin , Patanwala, Azima Muzzammil, Premvignesh, Prasanna Appiya, Maher, Yamen , Majie, Ankit , Gorain, Bapi , Dutta, PhD, Sulagna , Sengupta, PhD, Pallav , Maldonado Rosas, Israel , Roychoudhury, Shubhadeep

  • April 9, 2026

Related Content

Non-linear saturation threshold of gonadotropin dose on cumulative live birth rates in advanced-age women with polycystic ovary syndrome: a retrospective cohort study

The Loan Cap That Could Shrink the Doctor Pipeline

New federal limits on medical school borrowing may quietly reshape who becomes a physician—and where they practice.

Shared immune-inflammatory gene networks and drug prediction in polycystic ovary syndrome and type 2 diabetes mellitus: a bioinformatics and experimental validation study