Objective:

To identify key clinical and imaging clues on CT and MRI that can suggest the diagnosis of hepatic AL amyloidosis.

Approach:

Key Findings:

• All patients presented with hepatomegaly (10/10, 100%).
• Nine patients experienced abdominal distension (9/10, 90%).
• Laboratory findings showed markedly elevated alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) in all patients (10/10, 100%).
• CT imaging revealed diffuse hepatomegaly with decreased hepatic attenuation in all 8 patients who underwent CT.
• MRI showed marked hepatomegaly with smooth margins and vascular rarefaction in 6 patients who underwent MRI.
• Delayed enhancement was observed in all patients who underwent contrast-enhanced CT/MRI.
• All patients exhibited poor visualization or stenosis of the main hepatic veins and periportal edema.

Interpretation:

Hepatic AL amyloidosis should be suspected in patients with unexplained hepatomegaly, elevated ALP/GGT, and specific imaging findings.

Limitations:

• Small sample size of only 10 patients.
• Retrospective nature may limit the comprehensiveness of data.

Conclusion:

Recognition of clinical and imaging clues can improve diagnostic accuracy and timely recognition of hepatic AL amyloidosis.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.