To evaluate the significance of intermediate- and long-term outcomes of allogeneic ocular surface stem cell transplantation (OSST) for limbal stem cell deficiency.
Key Findings:
OSST is associated with improvement in visual acuity and ocular surface stability, though success rates vary widely by technique, ranging from 13% to 87%, highlighting the need for careful technique selection.
Triple-agent immunosuppression regimens show higher long-term success rates compared to single- or dual-agent approaches.
lr-CLAL may have advantages over KLAL due to lower rejection rates.
Long-term data for newer techniques like allo-CLET and allo-SLET remain limited.
Interpretation:
Careful postoperative monitoring and management of complications, including rejection, glaucoma, and microbial keratitis, are essential to optimize outcomes.
Limitations:
Limited long-term data for newer OSST techniques.
Variability in success rates among different surgical techniques.
Potential biases in the studies reviewed may affect the reliability of outcomes.
Conclusion:
OSST techniques can effectively restore ocular surface integrity, but outcomes depend on the chosen method and immunosuppression strategy.
