TPPU protects against seizures and seizure-associated comorbidities by inhibiting the Akt/mTOR signaling pathway in KA-induced convulsant mice - Summary - MDSpire

TPPU protects against seizures and seizure-associated comorbidities by inhibiting the Akt/mTOR signaling pathway in KA-induced convulsant mice

  • By

  • Rong Tang

  • Banglian Hu

  • Sulan Xie

  • Yijun Shen

  • Ziwei Wang

  • Xingyi Wang

  • Xiaohua Huang

  • Guoqiang Fei

  • Weifeng Peng

  • Honghua Zheng

  • Jing Ding

  • Xin Wang

  • June 8, 2026

  • 0 min

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Objective:

To investigate the anti-epileptic and comorbidity-alleviating effects of TPPU and the underlying molecular mechanisms in a KA-induced chronic epileptic model.

Key Findings:
  • TPPU significantly mitigated seizure severity and anxiety/depressive-like behaviors.
  • TPPU enhanced cognitive function in KA-induced chronic epileptic mice.
  • TPPU reduced neuronal apoptosis and neuroinflammation.
  • Bulk RNA-sequencing indicated that TPPU protects against neuroinflammation during epileptogenesis.
  • TPPU suppresses Akt/mTOR pathway activation.
Interpretation:

Remove unsupported conclusions about the Akt/mTOR axis.

Limitations:
Conclusion:

Remove implications about advancing understanding and identifying targets.

Original Source(s)

TPPU protects against seizures and seizure-associated comorbidities by inhibiting the Akt/mTOR signaling pathway in KA-induced convulsant mice

  • by Rong Tang, Banglian Hu, Sulan Xie, Yijun Shen, Ziwei Wang, Xingyi Wang, Xiaohua Huang, Guoqiang Fei, Weifeng Peng, Honghua Zheng, Jing Ding, Xin Wang

  • June 8, 2026

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