Genetic predictors of neurocognitive outcomes in survivors of pediatric brain tumors - Summary - MDSpire

Genetic predictors of neurocognitive outcomes in survivors of pediatric brain tumors

  • By

  • Sydney T. Grob

  • Kristen R. Miller

  • Bridget Sanford

  • Andrew M. Donson

  • Kenneth Jones

  • Andrea M. Griesinger

  • Vladimir Amani

  • Nicholas K. Foreman

  • Arthur Liu

  • Michael Handler

  • Todd C. Hankinson

  • Sarah Milgrom

  • Jean M. Mulcahy Levy

  • October 25, 2023

  • 0 min

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Objective:

To investigate the association between somatic genetic variants in DNA repair genes and neurocognitive outcomes, specifically IQ scores, in children treated for brain tumors.

Key Findings:
  • corrected_percentage
Interpretation:

The study suggests that specific genetic variants may influence neurocognitive outcomes in pediatric brain tumor survivors, highlighting the potential for personalized treatment strategies.

Limitations:
  • Small sample size may limit the generalizability of findings.
  • Exclusion of patients with pre-existing neurocognitive deficits may bias results.
Conclusion:

Identifying genetic predictors of neurocognitive outcomes could enhance treatment stratification and early intervention for at-risk pediatric brain tumor survivors.

Original Source(s)

Genetic predictors of neurocognitive outcomes in survivors of pediatric brain tumors

  • by Sydney T. Grob, Kristen R. Miller, Bridget Sanford, Andrew M. Donson, Kenneth Jones, Andrea M. Griesinger, Vladimir Amani, Nicholas K. Foreman, Arthur Liu, Michael Handler, Todd C. Hankinson, Sarah Milgrom, Jean M. Mulcahy Levy

  • October 25, 2023

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