Late enhancement and washout maps for distinguishing tumor progression from radiation necrosis in malignant brain tumors: an exploratory study - Summary - MDSpire
To examine whether delayed-enhancement and washout maps could help distinguish true tumor progression from radiation necrosis in follow-up MRI of patients with malignant brain tumors.
Approach:
Design and participants: Single-center retrospective observational study of adults with selected malignant brain tumors and newly appearing contrast-enhancing lesions on follow-up MRI after surgery and radiochemotherapy.
MRI acquisition and processing: T1-weighted images were acquired approximately 5–9 and 25–29 minutes after contrast administration. Images were co-registered, intensity-normalized, and subtracted to generate washout maps.
Measurements and diagnosis: Two readers independently assessed lesion enhancement, washout and delayed-enhancement volumes, alongside perfusion and diffusion measures. Histopathology was used when available; otherwise, diagnosis was based on clinical assessment and MRI follow-up of at le…
Interpretation:
The provided article context describes the study rationale and methods but does not report study results.
Limitations:
The supplied context does not include the sample size, diagnostic performance, or other study results.
The study was retrospective and conducted at a single center.
Conclusion:
The study evaluated temporally resolved contrast-enhanced MRI as a potential means of differentiating tumor progression from radiation necrosis; no outcome data are provided in the supplied context.
by Eya Khadhraoui, Leon Schmidt, Stefan Klebingat, I Erol Sandalcioglu, Roland Schwab, Philipp Arndt, Daniel Behme, Klaus-Peter Stein, Sebastian Johannes Müller
Baptist Health will bring together leading physicians, researchers and healthcare professionals from South Florida and across the country for the 14th Annual Baptist Health Miami Neuroscience Symposium, taking place Nov. 4-6, 2026, at Hilton Miami Dadeland and virtually via Zoom.
