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A post-hoc meta-analysis examined the influence of iris color on the efficacy of low-dose atropine in myopia management.
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The study found that children with non-brown irides showed significantly less myopia progression with atropine 0.01% compared to placebo.
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No significant treatment effect was observed in children with brown irides treated with atropine 0.01%, suggesting potential reduced efficacy.
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Atropine 0.05% did not show iris color-related differences in efficacy, indicating higher concentrations may overcome potential limitations.
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The findings raise questions about tailoring atropine dosing based on iris color, though the authors caution against immediate practice changes.
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