Successful treatment of refractory focal eosinophilic myositis with extra-ocular muscle involvement using tocilizumab: a case report - Takeaways - MDSpire

Successful treatment of refractory focal eosinophilic myositis with extra-ocular muscle involvement using tocilizumab: a case report

  • By

  • Haijun Liu

  • Qianhua Li

  • Xia Ouyang

  • Shuyu Chen

  • Henglun Liang

  • Yufeng Ye

  • Huiyuan Cao

  • Yong Xue

  • Lie Dai

  • May 25, 2026

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  • 1

    Eosinophilic myositis (EM) is a rare inflammatory myopathy characterized by eosinophilic infiltration of skeletal muscle.

  • 2

    Focal eosinophilic myositis (FEM) typically presents with localized muscle inflammation, often affecting the limbs.

  • 3

    A 65-year-old woman with multifocal FEM experienced a relapse involving extra-ocular muscles after glucocorticoid tapering.

  • 4

    The ocular relapse was refractory to glucocorticoids and multiple immunosuppressive agents but improved with tocilizumab treatment.

  • 5

    This case suggests that extra-ocular muscle involvement in FEM may indicate a more treatment-resistant phenotype.

Original Source(s)

Successful treatment of refractory focal eosinophilic myositis with extra-ocular muscle involvement using tocilizumab: a case report

  • by Haijun Liu, Qianhua Li, Xia Ouyang, Shuyu Chen, Henglun Liang, Yufeng Ye, Huiyuan Cao, Yong Xue, Lie Dai

  • May 25, 2026

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