Cortical high-threshold and low-activation characteristics in adolescent depression: a cross-age differential analysis

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Adolescent depression shows distinct neurophysiological features, particularly in resting motor threshold (RMT) and cortical activation.
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The study involved 85 treatment-naive patients divided into three age groups: adolescents, young adults, and middle-aged individuals.
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Adolescents had a significantly higher RMT and lower prefrontal oxyhemoglobin activation compared to other age groups.
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A strong negative correlation exists between RMT and cortical activation, while a strong positive correlation is found between RMT and depression severity.
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High RMT and low cortical activation in adolescents serve as neurobiological markers for depression severity, guiding tailored neuromodulation strategies.

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