Immunosuppressive contribution of tumour-infiltrating B cells in human intrahepatic cholangiocarcinoma and their role in chemoimmunotherapy outcome - Takeaways - MDSpire

Immunosuppressive contribution of tumour-infiltrating B cells in human intrahepatic cholangiocarcinoma and their role in chemoimmunotherapy outcome

  • By

  • Giulia Milardi

  • Barbara Franceschini

  • Chiara Camisaschi

  • Simone Puccio

  • Guido Costa

  • Cristiana Soldani

  • Paolo Uva

  • Davide Cangelosi

  • Roberta Carriero

  • Luca Lambroia

  • Antonella Cammarota

  • Giulio Lodetti-Zangrandi

  • Ines Malenica

  • Marco Erreni

  • Ilaria Montali

  • Tiziano Lottini

  • Chiara Raggi

  • Paolo Kunderfranco

  • Michela Anna Polidoro

  • Alessio Aghemo

  • Rita Balsano

  • Tiziana Pressiani

  • Salvatore Piscuoglio

  • Luca Di Tommaso

  • Guido Torzilli

  • Lorenza Rimassa

  • Enrico Lugli

  • Barbara Cassani

  • Ana Lleo

  • June 1, 2026

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  • 1

    Intrahepatic cholangiocarcinoma (iCCA) has a poor prognosis and is characterized by a chronically inflamed and immunosuppressive tumor microenvironment.

  • 2

    High densities of B cells in peritumoral areas are linked to improved disease-free survival, indicating a potential protective role.

  • 3

    Tumor-infiltrating B cells in iCCA are primarily immature and functionally suppressed due to influences from primary tumor cells and cancer-associated fibroblasts.

  • 4

    BAFFR+ B cells in peripheral blood can predict responses to chemoimmunotherapy, suggesting their role as biomarkers.

  • 5

    Targeting B-cell interactions within the tumor microenvironment may provide new therapeutic strategies to enhance immunotherapy efficacy in iCCA.

Original Source(s)

Immunosuppressive contribution of tumour-infiltrating B cells in human intrahepatic cholangiocarcinoma and their role in chemoimmunotherapy outcome

  • by Giulia Milardi, Barbara Franceschini, Chiara Camisaschi, Simone Puccio, Guido Costa, Cristiana Soldani, Paolo Uva, Davide Cangelosi, Roberta Carriero, Luca Lambroia, Antonella Cammarota, Giulio Lodetti-Zangrandi, Ines Malenica, Marco Erreni, Ilaria Montali, Tiziano Lottini, Chiara Raggi, Paolo Kunderfranco, Michela Anna Polidoro, Alessio Aghemo, Rita Balsano, Tiziana Pressiani, Salvatore Piscuoglio, Luca Di Tommaso, Guido Torzilli, Lorenza Rimassa, Enrico Lugli, Barbara Cassani, Ana Lleo

  • June 1, 2026

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