Early neural shift detection using functional magnetic resonance imaging: a pilot study with Parkinson’s disease patients undergoing istradefylline and hybrid assistive limb interventions

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The study involved six Parkinson's disease patients receiving either istradefylline or HAL therapy to assess early neural shifts via fMRI.
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Istradefylline treatment for one month resulted in increased brain activation related to motor and cognitive functions, as shown by fMRI.
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No significant clinical improvements were observed in cognitive, motor, mood, sleep, or quality of life metrics after treatment.
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Functional MRI may serve as a more sensitive biomarker for detecting early neural changes compared to traditional clinical assessments.
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The pilot study's findings should be interpreted cautiously due to the small sample size and exploratory nature of the research.

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