Quantifying the metabolic-inflammatory axis: synergistic value of TyG index and FAI in assessing CAD risk among MAFLD patients - Takeaways - MDSpire

Quantifying the metabolic-inflammatory axis: synergistic value of TyG index and FAI in assessing CAD risk among MAFLD patients

  • By

  • Xiaolong Bai

  • Zhijun Wang

  • Ziyi Cao

  • Junping Zhen

  • May 28, 2026

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  • 1

    The study evaluated the relationship between coronary inflammation and insulin resistance in patients with metabolic dysfunction-associated fatty liver disease (MAFLD).

  • 2

    A total of 435 patients were included, with 174 having MAFLD and 261 having both MAFLD and coronary heart disease (CHD).

  • 3

    The triglyceride-glucose (TyG) index and fat attenuation index (FAI) were identified as independent risk factors for CHD and coronary functional ischemia.

  • 4

    A nomogram integrating the TyG index, FAI, and clinical variables demonstrated excellent predictive performance for identifying high-risk CHD patients.

  • 5

    The study found a linear positive correlation between the TyG index and FAI, both associated with increased risk of CHD and functional ischemia.

Original Source(s)

Quantifying the metabolic-inflammatory axis: synergistic value of TyG index and FAI in assessing CAD risk among MAFLD patients

  • by Xiaolong Bai, Zhijun Wang, Ziyi Cao, Junping Zhen

  • May 28, 2026

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