Metachronous multicentric giant cell tumor of bone with pulmonary metastases: a case report with 20-year follow-up

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Metachronous multicentric giant cell tumor of bone (MGCTB) with pulmonary metastases is an exceedingly rare and challenging condition.
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The patient, a 38-year-old male, was followed for over 20 years, undergoing multiple surgical interventions for MGCTB.
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Denosumab therapy, initiated in 2017, achieved sustained disease stabilization despite previous treatment failures.
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A treatment interruption during the COVID-19 pandemic led to disease progression, necessitating further surgical intervention.
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This case highlights the importance of continuous systemic therapy in managing advanced MGCTB and controlling metastatic disease.

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