Pathological fracture following minimal trauma as the initial presentation of parathyroid carcinoma–associated hyperparathyroidism in a young man: a case report

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Parathyroid carcinoma is a rare malignant tumor, accounting for approximately 0.005% of all malignancies and a rare cause of primary hyperparathyroidism.
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A 36-year-old man presented with a pathological fracture after minimal trauma, highlighting an atypical initial manifestation of parathyroid carcinoma.
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Laboratory evaluation revealed severe hypercalcemia and markedly elevated parathyroid hormone levels, consistent with primary hyperparathyroidism.
4

Surgical resection confirmed the diagnosis of parathyroid carcinoma, emphasizing the need for careful evaluation in cases of unexplained hypercalcemia.
5

This case underscores the importance of considering endocrine causes in patients with pathological fractures and recurrent nephrolithiasis.

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