Combination Therapy Targets Bacterial Keratitis June 4, 2026 The Ophthalmologist Share Summary Takeaways Listen Insight Report Clinical Scorecard Quiz Poll Top Institutions Topic Commentary 1 A combination of levofloxacin and ibuprofen may enhance treatment for bacterial keratitis amid rising antimicrobial resistance. 2 In a rat model, combination therapy outperformed monotherapy in microbiological, molecular, and histological assessments. 3 Ibuprofen reduced the minimum inhibitory concentration of levofloxacin, indicating enhanced antibacterial potency. 4 Combination therapy resulted in lower inflammatory cytokine expression and improved corneal architecture compared to monotherapy. 5 The study's findings are exploratory, limited by small sample size and focus on Staphylococcus aureus, necessitating further research.
