Transgenerational exposure to plastics-derived endocrine‐disrupting bisphenol A and its analogs on male infertility: impact of gut dysbiosis and epigenetic regulation

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Bisphenol A (BPA) exposure is linked to declining male fertility rates, affecting sperm count, motility, and quality.
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BPA alters gut microbial composition, leading to dysbiosis, which can impact systemic inflammation and reproductive function.
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Transgenerational effects of BPA exposure may cause epigenetic changes that affect male fertility across generations.
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BPA mimics hormones and disrupts endocrine signaling, particularly affecting Leydig and Sertoli cells, contributing to infertility.
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Understanding BPA's impact on the gut-reproductive axis is crucial for developing strategies to protect male reproductive health.

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