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1
Serum IL-6 levels significantly vary across 10 neurological disorders, with the highest levels in traumatic brain injury, metabolic/toxic encephalopathy, and hemorrhagic stroke.
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2
Independent predictors of serum IL-6 levels include disease category, age with a U-shaped association, and male sex, all showing statistical significance.
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3
IL-6 demonstrates strong diagnostic performance for distinguishing acute brain injuries from healthy individuals, with AUC values exceeding 0.9 for several conditions.
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4
The diagnostic utility of IL-6 is limited for differentiating between various neurological diseases, particularly between traumatic brain injury and others.
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5
A proposed clinical interpretation framework for serum IL-6 testing requires further validation in multi-center studies to confirm its utility in emergency settings.
