OxLDL-induced ferroptosis and pyroptosis in atherosclerosis: a mini review - Takeaways - MDSpire

OxLDL-induced ferroptosis and pyroptosis in atherosclerosis: a mini review

  • By

  • Shaozhi Liu

  • Yuxia Wu

  • Lei Chen

  • Li Hu

  • Jinjin Yin

  • May 28, 2026

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  • 1

    OxLDL triggers ferroptosis and pyroptosis, contributing to plaque progression and instability in atherosclerosis.

  • 2

    Ferroptosis is characterized by iron-dependent lipid peroxidation and is suppressed by glutathione peroxidase 4.

  • 3

    Pyroptosis involves inflammasome-activated gasdermin D, leading to pore formation and inflammatory cytokine release.

  • 4

    There is significant crosstalk between ferroptosis and pyroptosis, establishing a positive feedback loop that amplifies vascular inflammation.

  • 5

    Understanding the integrated cell death network may provide new insights for addressing residual inflammatory risk in atherosclerotic cardiovascular disease.

Original Source(s)

OxLDL-induced ferroptosis and pyroptosis in atherosclerosis: a mini review

  • by Shaozhi Liu, Yuxia Wu, Lei Chen, Li Hu, Jinjin Yin

  • May 28, 2026

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