Opioid overdose and cardiovascular disease-related mortality: a retrospective analysis using real-world data from the USA, 1999–2023 - Takeaways - MDSpire

Opioid overdose and cardiovascular disease-related mortality: a retrospective analysis using real-world data from the USA, 1999–2023

  • By

  • Mohamed Fawzi Hemida

  • Alyaa Ahmed Ibrahim

  • Maryam Saghir

  • Ahmed Elshahat

  • Mohammad Rayyan Faisal

  • Moaz Elsayed Abouelmagd

  • Zeyad Kholeif

  • Krish Patel

  • Noha Hammad

  • Pakeezah Tabasum

  • Eshal Saghir

  • Mohammed Hammad Jaber Amin

  • Ahmed Elmorsy Mohamed

  • Khaled Ali

  • Basel Abdelazeem

  • Mustafa Al-jarshawi

  • May 13, 2026

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  • 1

    The study analyzed 112,430 deaths involving opioid overdose and cardiovascular disease (CVD) from 1999 to 2023 using CDC WONDER data.

  • 2

    Age-adjusted mortality rates for opioid overdose and CVD increased significantly, from 0.36 in 1999 to 4.08 in 2023, with an average annual percent change of 10.96.

  • 3

    Men exhibited higher mortality rates than women, with overall age-adjusted mortality rates of 2.51 for men compared to 0.99 for women.

  • 4

    Non-Hispanic Black individuals experienced the steepest increase in mortality rates, rising from 0.33 in 1999 to 6.48 in 2023.

  • 5

    Non-metropolitan areas had consistently higher mortality rates than metropolitan areas, highlighting significant regional disparities in opioid and CVD-related deaths.

Original Source(s)

Opioid overdose and cardiovascular disease-related mortality: a retrospective analysis using real-world data from the USA, 1999–2023

  • by Mohamed Fawzi Hemida, Alyaa Ahmed Ibrahim, Maryam Saghir, Ahmed Elshahat, Mohammad Rayyan Faisal, Moaz Elsayed Abouelmagd, Zeyad Kholeif, Krish Patel, Noha Hammad, Pakeezah Tabasum, Eshal Saghir, Mohammed Hammad Jaber Amin, Ahmed Elmorsy Mohamed, Khaled Ali, Basel Abdelazeem, Mustafa Al-jarshawi

  • May 13, 2026

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