Sex differences in peripheral and local immune responses following spinal cord injury - Takeaways - MDSpire

Sex differences in peripheral and local immune responses following spinal cord injury

  • By

  • Sara Rito-Fernandes

  • Andreia Monteiro

  • Maria M. Moura

  • Juliana Fiúza-Fernandes

  • Sara M. Pinto

  • Marta F. Lima

  • João L. Afonso

  • Inês Pereira

  • Bárbara Carneiro-Pereira

  • Luís S. Fernandes

  • Filipa Ferreira-Antunes

  • Ana T. Palha

  • André Vidinha-Mira

  • António J. Salgado

  • Nuno A. Silva

  • Susana Monteiro

  • May 25, 2026

Share

  • 1

    Biological sex significantly influences immune function and inflammatory responses after spinal cord injury (SCI).

  • 2

    Males show higher frequencies of circulating myeloid cells post-SCI, while females have more myeloid cells in the spinal cord.

  • 3

    Females initiate a favorable immune response for tissue repair earlier than males after spinal cord injury.

  • 4

    Sex-specific immune responses continue to develop at later stages post-SCI, affecting recovery outcomes.

  • 5

    The study emphasizes the need for sex-inclusive research in SCI to improve understanding and therapeutic strategies.

Original Source(s)

Sex differences in peripheral and local immune responses following spinal cord injury

  • by Sara Rito-Fernandes, Andreia Monteiro, Maria M. Moura, Juliana Fiúza-Fernandes, Sara M. Pinto, Marta F. Lima, João L. Afonso, Inês Pereira, Bárbara Carneiro-Pereira, Luís S. Fernandes, Filipa Ferreira-Antunes, Ana T. Palha, André Vidinha-Mira, António J. Salgado, Nuno A. Silva, Susana Monteiro

  • May 25, 2026

Related Content

MRI May Define Two Distinct Migraine Phenotypes

Patients with greater migraine burden showed widespread connectivity changes and lower cortical volume.

2026 Brain and Spine Symposium Highlights Advances Across the Neurosciences

Over two days, specialists across neurology, neurosurgery and related subspecialties came together to discuss advances in stroke care, epilepsy, movement disorders, neurodegenerative disease, neuro-oncology, brain and spine surgery, interventional pain management and emerging technologies.

  • by

  • May 21, 2026

  • 1 min
Baptist Health Foundation Presents Endowed Chair Ceremony for Aviva Abosch, M.D., Ph.D.

Aviva Abosch, M.D., Ph.D., a neurosurgeon at Baptist Health Miami Neuroscience Institute, part of Baptist Health Brain and Spine Care, was installed as the Esernia Endowed Chair in Surgical Treatment of Adult Epilepsy and Movement Disorders.

  • by

  • May 21, 2026

  • 5 min