Research and development of novel embolization materials and study on their feasibility of preventing T2EL after EVAR abdominal aortic aneurysm - Takeaways - MDSpire

Research and development of novel embolization materials and study on their feasibility of preventing T2EL after EVAR abdominal aortic aneurysm

  • By

  • E. Erdemutu

  • Boru Huang

  • Liqiang Hu

  • Shaohong Yin

  • Ying Lan

  • Chongbin Zhou

  • Xiangchen Dai

  • June 1, 2026

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  • 1

    The study developed a novel embolization material, Thrombin-Coated Controllable Coil (TCC), to prevent Type II Endoleak after Endovascular Aneurysm Repair.

  • 2

    TCC demonstrated superior coagulation efficiency, significantly shortening coagulation time compared to interlocking detachable coils and control groups.

  • 3

    In vitro, TCC promoted apoptosis in vascular smooth muscle cells while minimally affecting vascular endothelial cells.

  • 4

    In vivo tests showed TCC effectively prevented Type II Endoleak and achieved complete thrombosis without complications in a minipig model.

  • 5

    Transcriptomic analysis revealed significant gene expression changes associated with TCC treatment, indicating its potential biological mechanisms.

Original Source(s)

Research and development of novel embolization materials and study on their feasibility of preventing T2EL after EVAR abdominal aortic aneurysm

  • by E. Erdemutu, Boru Huang, Liqiang Hu, Shaohong Yin, Ying Lan, Chongbin Zhou, Xiangchen Dai

  • June 1, 2026

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