Systemic dysregulation of essential and toxic elements and redox homeostasis in gynecologic malignancies - Takeaways - MDSpire

Systemic dysregulation of essential and toxic elements and redox homeostasis in gynecologic malignancies

  • By

  • Paweł Ordon

  • Kacper Boroń

  • Krzysztof Bereza

  • Dariusz Boroń

  • Piotr Ossowski

  • Tomasz Sirek

  • Agata Sirek

  • Julia Gajdeczka

  • Beniamin Oskar Grabarek

  • May 15, 2026

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  • 1

    Endometrial cancer and ovarian cancer exhibit distinct alterations in essential and toxic element levels and redox balance.

  • 2

    Higher tumor grades in endometrial cancer correlate with lower levels of calcium, magnesium, and iron, alongside increased manganese, copper, lead, and cadmium.

  • 3

    Ovarian cancer patients show similar elemental changes, particularly those undergoing surgery followed by chemotherapy.

  • 4

    Redox profiling indicates decreased total antioxidant status and increased total oxidant status across tumor grades in both cancers.

  • 5

    The study highlights the need for further research to clarify the clinical relevance of elemental and redox changes in gynecologic cancers.

Original Source(s)

Systemic dysregulation of essential and toxic elements and redox homeostasis in gynecologic malignancies

  • by Paweł Ordon, Kacper Boroń, Krzysztof Bereza, Dariusz Boroń, Piotr Ossowski, Tomasz Sirek, Agata Sirek, Julia Gajdeczka, Beniamin Oskar Grabarek

  • May 15, 2026

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