Peripheral cytotoxic immune profiles in hepatobiliary surgical patients

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The study analyzed cytotoxic immune profiles in 245 hepatobiliary surgical patients using flow cytometry.
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NK cells exhibited higher cytotoxic marker expression compared to T-cell subsets across all disease categories.
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Age significantly correlated with all cytotoxic markers, indicating that immunosenescence primarily drives expression.
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CD8+Perforin+ levels were higher in severe acute pancreatitis cases, suggesting its potential as a severity marker.
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Principal component analysis revealed two immune axes and three distinct immune phenotypes not linked to disease categories.

Frontiers In Immunology

by Zhen Li, Dongping Yu, Lingyong Liu, Qi Zuo, Jiaqi Wang, Xiangjuan Jiao, Zhi Duan, Dong Chen
June 3, 2026

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