Targeting VISTA for immunomodulation in sepsis: mechanisms and therapeutic potentials - Takeaways - MDSpire

Targeting VISTA for immunomodulation in sepsis: mechanisms and therapeutic potentials

  • By

  • Baoji Hu

  • Jiangbin Yan

  • Wentao Ji

  • Huixian Wang

  • Tianzhu Tao

  • Lulong Bo

  • May 29, 2026

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  • 1

    Sepsis is a life-threatening syndrome characterized by acute organ dysfunction due to a dysregulated immune response to infection.

  • 2

    VISTA is an immune checkpoint molecule that plays a crucial role in regulating immune responses during different stages of sepsis.

  • 3

    In the early phase of sepsis, VISTA signaling may help mitigate hyperinflammation, while in later stages, it can contribute to T cell hyporesponsiveness.

  • 4

    Current research emphasizes the need for precision immunomodulatory strategies targeting VISTA to improve outcomes in sepsis patients.

  • 5

    The review highlights the potential of VISTA-targeted therapies, while noting the challenges in linking VISTA dynamics to clinical outcomes.

Original Source(s)

Targeting VISTA for immunomodulation in sepsis: mechanisms and therapeutic potentials

  • by Baoji Hu, Jiangbin Yan, Wentao Ji, Huixian Wang, Tianzhu Tao, Lulong Bo

  • May 29, 2026

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