Remodeling the gut-heart axis: Danggui Sini granule mitigates vasospastic coronary heart disease via microbiota-metabolite interactions - Takeaways - MDSpire

Remodeling the gut-heart axis: Danggui Sini granule mitigates vasospastic coronary heart disease via microbiota-metabolite interactions

  • By

  • Haipeng Tang

  • Zhiliang Sun

  • Shanshan Wang

  • Zhi Chen

  • Wenzhu Wang

  • Yang Wang

  • Jiyu Gong

  • Xiaoyan Xie

  • Wenyi Gao

  • May 22, 2026

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  • 1

    Danggui Sini Granule (DSG) is used clinically to improve cardiovascular circulation and alleviate ischemic symptoms in coronary heart disease (CHD).

  • 2

    In a rat model, DSG treatment reduced myocardial injury, dyslipidemia, and inflammatory markers associated with vasospastic CHD.

  • 3

    16S rRNA sequencing revealed DSG's ability to modulate gut microbiota, decreasing pathogenic genera and enriching beneficial taxa.

  • 4

    Metabolomics indicated DSG partially mitigated CHD-related disturbances, restoring protective lipid mediators and influencing metabolic pathways.

  • 5

    Molecular docking suggested favorable interactions between DSG components and key targets, supporting its cardioprotective effects through gut-heart-axis modulation.

Original Source(s)

Remodeling the gut-heart axis: Danggui Sini granule mitigates vasospastic coronary heart disease via microbiota-metabolite interactions

  • by Haipeng Tang, Zhiliang Sun, Shanshan Wang, Zhi Chen, Wenzhu Wang, Yang Wang, Jiyu Gong, Xiaoyan Xie, Wenyi Gao

  • May 22, 2026

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