The interplay of maturity-onset diabetes of the young, obesity, uncontrolled hypertension, and cannabinoid hyperemesis in the progression to end-stage renal disease: a case report

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A 24-year-old male with suspected MODY, obesity, and uncontrolled hypertension advanced to end-stage renal disease within five years of diagnosis.
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The patient's renal function deteriorated significantly, with serum creatinine rising from 0.9 to 10.8 mg/dL and eGFR declining from 115.98 to 4.69 mL/min/1.73 m².
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Despite treatment with insulin and metformin, the patient's glycemic control remained poor, with a mean HbA1c of 9.79% over the study period.
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Chronic cannabis use contributed to recurrent acute kidney injury and exacerbated the patient's renal decline, leading to prerenal azotemia.
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This case highlights the urgent need for early identification and comprehensive management of patients at high risk for rapid renal deterioration.

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