Sex-specific effects of digital home-based neuromodulation combined with mindfulness-based meditation on knee osteoarthritis symptoms - Takeaways - MDSpire

Sex-specific effects of digital home-based neuromodulation combined with mindfulness-based meditation on knee osteoarthritis symptoms

  • By

  • Chiyoung Lee

  • Juyoung Park

  • Chen X. Chen

  • Xiaoxiao Sun

  • C. Kent Kwoh

  • Shen Liu

  • Hongyu Miao

  • Hyochol Ahn

  • May 30, 2026

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  • 1

    Transcranial direct current stimulation (tDCS) is a non-invasive technique that modulates cortical excitability and may alleviate pain in knee osteoarthritis (KOA).

  • 2

    Mindfulness-based meditation (MBM) has been shown to effectively manage chronic pain and may enhance pain-related brain function in individuals with KOA.

  • 3

    Combining tDCS with MBM could activate complementary mechanisms in pain processing, potentially improving knee-specific clinical pain and symptoms.

  • 4

    Sex differences significantly influence individual responses to tDCS and mindfulness interventions, necessitating a sex-stratified design in research.

  • 5

    A digitally delivered, home-based model of tDCS and MBM is feasible, safe, and associated with high adherence rates among individuals with KOA.

Original Source(s)

Sex-specific effects of digital home-based neuromodulation combined with mindfulness-based meditation on knee osteoarthritis symptoms

  • by Chiyoung Lee, Juyoung Park, Chen X. Chen, Xiaoxiao Sun, C. Kent Kwoh, Shen Liu, Hongyu Miao, Hyochol Ahn

  • May 30, 2026

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