Early high-resolution immune profiles are associated with survival, relapse and graft-versus-host-disease after allogeneic hematopoietic cell transplantation - Takeaways - MDSpire

Early high-resolution immune profiles are associated with survival, relapse and graft-versus-host-disease after allogeneic hematopoietic cell transplantation

  • By

  • Patrick Terrence Brooks

  • Lia Minculescu

  • Hans Jakob Hartling

  • Rebecca Svanberg Teglgaard

  • Jose Antonio Salado-Jimena

  • Lone Smidstrup Friis

  • Brian Kornblit

  • Ida Schjødt

  • Søren Lykke Petersen

  • Niels Smedegaard Andersen

  • Jens Lundgren

  • Susanne Dam Nielsen

  • Lars Klingen Gjærde

  • Hanne Vibeke Marquart

  • Henrik Sengeløv

  • Sisse Rye Ostrowski

  • May 30, 2026

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  • 1

    The study evaluated immune profiles in 77 adult allo-HCT recipients at day +28 post-transplantation to assess associations with clinical outcomes.

  • 2

    Increased immune cell counts and elevated cytokine-release responses were linked to improved survival and lower relapse incidence in allo-HCT patients.

  • 3

    Higher CD4 T cell PD-1 expression and HLA-DR on CD8 T cells correlated with poorer overall survival among allo-HCT recipients.

  • 4

    The research emphasizes the significance of early innate immune reconstitution for monitoring allo-HCT patients and potential therapeutic targets.

  • 5

    High-resolution immunophenotyping combined with functional assays was utilized to investigate immune cell composition and activation status.

Original Source(s)

Early high-resolution immune profiles are associated with survival, relapse and graft-versus-host-disease after allogeneic hematopoietic cell transplantation

  • by Patrick Terrence Brooks, Lia Minculescu, Hans Jakob Hartling, Rebecca Svanberg Teglgaard, Jose Antonio Salado-Jimena, Lone Smidstrup Friis, Brian Kornblit, Ida Schjødt, Søren Lykke Petersen, Niels Smedegaard Andersen, Jens Lundgren, Susanne Dam Nielsen, Lars Klingen Gjærde, Hanne Vibeke Marquart, Henrik Sengeløv, Sisse Rye Ostrowski

  • May 30, 2026

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