Parvovirus B19 infection preceding the diagnosis of childhood myelodysplastic syndrome with low blasts: a case report - Takeaways - MDSpire

Parvovirus B19 infection preceding the diagnosis of childhood myelodysplastic syndrome with low blasts: a case report

  • By

  • Leah Klingel

  • Stefanie Huber

  • Irith Baumann

  • Stephan Schwarz-Furlan

  • Almut Meyer-Bahlburg

  • Holger Lode

  • June 5, 2026

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  • 1

    Parvovirus B19 infection can cause transient bone marrow suppression and pure red cell aplasia, particularly in patients with hematologic disorders.

  • 2

    A 7-year-old girl presented with pancytopenia during acute PVB19 infection, confirmed by high viral loads in blood and bone marrow.

  • 3

    Initial bone marrow examination showed hypocellularity and multilineage dysplasia, but did not meet criteria for myelodysplastic syndrome.

  • 4

    Comprehensive evaluation ruled out autoimmune diseases and inherited bone marrow failure syndromes, leading to a diagnosis of childhood MDS.

  • 5

    The patient underwent successful allogeneic hematopoietic stem cell transplantation and experienced persistent low-level PVB19 DNAemia post-transplant.

Original Source(s)

Parvovirus B19 infection preceding the diagnosis of childhood myelodysplastic syndrome with low blasts: a case report

  • by Leah Klingel, Stefanie Huber, Irith Baumann, Stephan Schwarz-Furlan, Almut Meyer-Bahlburg, Holger Lode

  • June 5, 2026

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