Stabilized adaptive states in microbiome–human integrated physiology: reframing health and chronic disease as symbiotic biological states - Takeaways - MDSpire

Stabilized adaptive states in microbiome–human integrated physiology: reframing health and chronic disease as symbiotic biological states

  • By

  • João Francisco Pollo Gaspary

  • Luis Felipe Dias Lopes

  • Fernanda Peron Gaspary

  • Eduarda Grando Lopes

  • Alfred Lee Edgar

  • Eduardo Poletti Camara

  • Antonio Geraldo Camara

  • May 14, 2026

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  • 1

    Chronic conditions often exhibit long-term stability and resistance to treatment, indicating a need for a new understanding of their organizational basis.

  • 2

    Microbiome research reveals that human physiology operates within a multigenomic system, influencing metabolic and signaling capacities.

  • 3

    The proposed framework interprets health and disease as stabilized adaptive states resulting from hierarchical signal integration in a multigenomic context.

  • 4

    Chronic pathology is viewed as coherent regulatory configurations rather than mere dysregulation, emphasizing membrane-level decisional architecture.

  • 5

    This model aims to clarify biological stabilization over time and generate testable hypotheses regarding state transitions and physiological flexibility.

Original Source(s)

Stabilized adaptive states in microbiome–human integrated physiology: reframing health and chronic disease as symbiotic biological states

  • by João Francisco Pollo Gaspary, Luis Felipe Dias Lopes, Fernanda Peron Gaspary, Eduarda Grando Lopes, Alfred Lee Edgar, Eduardo Poletti Camara, Antonio Geraldo Camara

  • May 14, 2026

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