ANXA2 promotes NLRP3 inflammasome activation and neuronal pyroptosis after intracerebral hemorrhage - Takeaways - MDSpire

ANXA2 promotes NLRP3 inflammasome activation and neuronal pyroptosis after intracerebral hemorrhage

  • By

  • Qingyuan Wu

  • Yuetao Wen

  • Yiqing Shen

  • XiangYu Chen

  • WenSong Yang

  • Limin Ma

  • Peng Xie

  • May 26, 2026

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  • 1

    Intracerebral hemorrhage (ICH) is a severe stroke type that lacks effective pharmacotherapy, contributing to high mortality and neurological deficits.

  • 2

    Pyroptosis, driven by NLRP3 inflammasome activation, significantly contributes to neuronal death following ICH.

  • 3

    ANXA2 was identified as a key hub protein that regulates NLRP3 inflammasome activation and neuronal pyroptosis after ICH.

  • 4

    Silencing ANXA2 reduced NLRP3 activation, decreased inflammatory cytokine secretion, and improved neurological outcomes in ICH models.

  • 5

    The study highlights a novel ANXA2–NLRP3–pyroptosis pathway, suggesting potential therapeutic targets for mitigating secondary brain injury after ICH.

Original Source(s)

ANXA2 promotes NLRP3 inflammasome activation and neuronal pyroptosis after intracerebral hemorrhage

  • by Qingyuan Wu, Yuetao Wen, Yiqing Shen, XiangYu Chen, WenSong Yang, Limin Ma, Peng Xie

  • May 26, 2026

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