Oliceridine effectively attenuates fentanyl-induced cough during general anesthesia induction - Takeaways - MDSpire

Oliceridine effectively attenuates fentanyl-induced cough during general anesthesia induction

  • By

  • Ru-Yi Xing

  • Wen-Yi Gong

  • Chen-Guang Li

  • Ilyar Mamtili

  • Shuang-Xiong Zhu

  • Wen-Jun Zhou

  • Bing-Xing Li

  • Jie Cao

  • Xiao-Fang Yue

  • Kun Fan

  • May 14, 2026

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  • 1

    Oliceridine significantly reduces the incidence of fentanyl-induced cough (FIC) during anesthesia induction compared to normal saline.

  • 2

    In the study, 0% of patients receiving oliceridine experienced FIC, while 58.33% in the saline group did (p < 0.001).

  • 3

    Cough severity in the saline group varied, with 17.86% classified as mild, 20.24% as moderate, and 20.24% as severe.

  • 4

    Vital signs remained stable with no significant changes between groups, indicating oliceridine's safety profile.

  • 5

    Oliceridine's use as a prophylactic agent during anesthesia induction offers a safe approach without increasing adverse risks.

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