Semaglutide Reduced Nicotine Craving in Small Trial - Takeaways - MDSpire

Semaglutide Reduced Nicotine Craving in Small Trial

  • By

  • Andrea Surnit

  • May 26, 2026

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  • 1

    Semaglutide reduced nicotine craving and body weight in smokers, but did not significantly decrease cigarettes smoked per day.

  • 2

    The trial involved 24 non-treatment-seeking adults who smoked at least 5 cigarettes daily, assigned to semaglutide or placebo for 9 weeks.

  • 3

    Participants receiving semaglutide lost about 5% of body weight, while those on placebo experienced a slight weight increase.

  • 4

    Exploratory analyses indicated semaglutide may reduce withdrawal symptoms and increase smoking abstinence self-efficacy.

  • 5

    The study's small size and short duration limit the generalizability of findings, particularly for broader smoking cessation efforts.

Original Source(s)

Semaglutide Reduced Nicotine Craving in Small Trial

  • by Andrea Surnit

  • May 26, 2026

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