Case Report: Primary sciatic leiomyosarcoma in a patient with neurofibromatosis type 1 - Takeaways - MDSpire

Case Report: Primary sciatic leiomyosarcoma in a patient with neurofibromatosis type 1

  • By

  • Longgang Chen

  • Meiling Xu

  • Kai Cheng

  • Lingya Cui

  • Xuefei Mou

  • Changhui Li

  • May 7, 2026

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  • 1

    A 56-year-old woman with neurofibromatosis type 1 presented with a primary sciatic leiomyosarcoma after an 8-month history of a growing thigh lump.

  • 2

    The tumor, measuring 14×11 cm, was surgically resected along with a segment of the sciatic nerve, achieving an R0 margin.

  • 3

    Histopathological analysis confirmed the diagnosis of leiomyosarcoma, showing severe anisocytosis and nerve invasion.

  • 4

    Postoperative recovery was uneventful, with no recurrence or metastasis observed during the six-month follow-up.

  • 5

    This case underscores the importance of considering leiomyosarcoma in NF1 patients and the need for multidisciplinary management.

Original Source(s)

Case Report: Primary sciatic leiomyosarcoma in a patient with neurofibromatosis type 1

  • by Longgang Chen, Meiling Xu, Kai Cheng, Lingya Cui, Xuefei Mou, Changhui Li

  • May 7, 2026

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