Painful penile mass as an initial manifestation of systemic diffuse large B-cell lymphoma: a case report - Takeaways - MDSpire
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Initial Presentation of Systemic Diffuse Large B-Cell Lymphoma as a Painful Penile Mass: A Case Study

  • By

  • Min-Jung Jan

  • Chia Hao Liang

  • Ming-Che Ou

  • Tang-Yi Tsao

  • Yi-Sheng Lin

  • Yen-Chuan Ou

  • Min-Che Tung

  • Chao-Yu Hsu

  • August 17, 2026

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  • 1

    Diffuse large B-cell lymphoma (DLBCL) of the penis is a rare malignancy often misdiagnosed as penile carcinoma or infections.

  • 2

    A 58-year-old man presented with a painful penile mass that did not improve with antibiotics, leading to a biopsy confirming DLBCL.

  • 3

    Imaging revealed intense uptake in the penis and gastric involvement, classifying the disease as Lugano stage IV.

  • 4

    The patient was treated with R-CHOP systemic chemo-immunotherapy, achieving complete metabolic remission.

  • 5

    This case highlights the importance of FDG PET/CT in diagnosing and staging DLBCL with extranodal involvement.

Original Source(s)

Painful penile mass as an initial manifestation of systemic diffuse large B-cell lymphoma: a case report

  • by Min-Jung Jan, Chia Hao Liang, Ming-Che Ou, Tang-Yi Tsao, Yi-Sheng Lin, Yen-Chuan Ou, Min-Che Tung, Chao-Yu Hsu

  • August 17, 2026

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