A clinical viewpoint on the EASO grade-based pharmacological algorithm for obesity management

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Obesity is classified into 'fat mass disease' and 'sick fat disease,' each linked to distinct complications requiring tailored management.
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Next-generation obesity management medications can induce significant weight loss and improve obesity-related complications, comparable to bariatric surgery.
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The EASO framework offers a grade-based pharmacological algorithm to guide clinicians in evaluating obesity treatment options based on scientific evidence.
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Limitations of the EASO framework include a lack of long-term data on weight loss durability and disparities in access to obesity management medications.
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Lifestyle interventions remain crucial for sustainable obesity management, emphasizing the importance of holistic care beyond just weight loss.

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