-
1
Preeclampsia involves placental hypoxia, metabolic stress, and trophoblast dysfunction, but the connections between these factors are not fully understood.
-
2
Cuproptosis is a regulated cell-death process linked to copper accumulation and may connect metabolic stress to trophoblast injury in preeclampsia.
-
3
Recent studies indicate copper dyshomeostasis in preeclampsia, with varying serum copper levels reported across different geographic regions.
-
4
Research has identified cuproptosis-associated genes in preeclampsia, linking metabolic dysregulation and disrupted copper transport to trophoblast dysfunction.
-
5
The proposed pathway suggests that placental hypoxia leads to lactate accumulation, which may epigenetically influence copper metabolism and trophoblast viability.
