Proteomics in uveal melanoma may enhance diagnosis, prognostication, and therapeutic discovery through analysis of proteins in blood and ocular fluids.
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Nearly 40% of uveal melanoma patients develop metastatic disease despite effective local control, highlighting the need for improved diagnostic methods.
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Aqueous humor proteomics can provide insights into tumor characteristics and has shown potential for better sensitivity than conventional liver function tests.
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Studies indicate that proteomic signatures in aqueous humor correlate with tumor characteristics, such as size and chromosomal alterations.
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Proteomics offers a less invasive alternative to traditional biopsy, allowing for repeated sampling and longitudinal monitoring of uveal melanoma.
