Biomarkers, Cognitive Function, and Mortality in Centenarians - Takeaways - MDSpire

Biomarkers, Cognitive Function, and Mortality in Centenarians

  • By

  • Ryo Shikimoto

  • Takashi Sasaki

  • Yukiko Abe

  • Kenji Tai

  • Nobuyoshi Hirose

  • Hideyuki Okano

  • Yasumichi Arai

  • May 7, 2026

  • 0 min

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  • 1

    Research emphasizes interactions between age-related neural changes and systemic processes rather than isolating them.

  • 2

    Centenarians can maintain cognitive function despite high levels of amyloid-β and phosphorylated tau, indicating alternative aging mechanisms.

  • 3

    Blood biomarkers like NfL, amyloid-β, and p-tau181 are linked to cognitive function and mortality, but no single biomarker is consistently validated.

  • 4

    A comprehensive assessment of physical and cognitive functions is crucial for understanding mortality risk in centenarians.

  • 5

    The study analyzed neural blood biomarkers in centenarians, revealing NfL's association with both cognitive function and mortality.

Original Source(s)

Biomarkers, Cognitive Function, and Mortality in Centenarians

  • by Ryo Shikimoto, Takashi Sasaki, Yukiko Abe, Kenji Tai, Nobuyoshi Hirose, Hideyuki Okano, Yasumichi Arai

  • May 7, 2026

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