Bidirectional Association Between Premenstrual Disorders and Psychiatric Disorders - Takeaways - MDSpire

Bidirectional Association Between Premenstrual Disorders and Psychiatric Disorders

  • By

  • Jing Zhou

  • Zeinab Muse

  • Emma Bränn

  • Yihui Yang

  • Elgeta Hysaj

  • Miriam Martini

  • Nora E. Verberne

  • Marion Opatowski

  • Astrid Kamperman

  • Helena Kopp Kallner

  • Elizabeth Bertone-Johnson

  • Donghao Lu

  • May 8, 2026

  • 0 min

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  • 1

    Premenstrual disorders (PMD) affect 20% to 30% of women, leading to significant mood disturbances and decreased quality of life.

  • 2

    Women with PMD have a higher likelihood of developing major depression and generalized anxiety disorders, with odds ratios of 4 and 7, respectively.

  • 3

    Genetic factors contribute to PMD, with heritability estimates ranging from 35% to 56%, indicating a shared genetic landscape with psychiatric disorders.

  • 4

    The study utilized multiple Swedish national registers to analyze the bidirectional relationship between PMD and psychiatric disorders.

  • 5

    Findings suggest that PMD and psychiatric disorders may influence each other, highlighting the need for comprehensive mental health assessments in affected women.

Original Source(s)

Bidirectional Association Between Premenstrual Disorders and Psychiatric Disorders

  • by Jing Zhou, Zeinab Muse, Emma Bränn, Yihui Yang, Elgeta Hysaj, Miriam Martini, Nora E. Verberne, Marion Opatowski, Astrid Kamperman, Helena Kopp Kallner, Elizabeth Bertone-Johnson, Donghao Lu

  • May 8, 2026

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