Efficacy and safety of high-intensity focused ultrasound versus cryoablation for breast fibroadenomas: a systematic review and meta-analysis

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High-intensity focused ultrasound (HIFU) achieved tumor volume reductions of 54.4% at 6 months and 70.3% at 12 months for breast fibroadenomas.
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Cryoablation demonstrated greater tumor volume reduction compared to HIFU, although quantitative aggregation was not possible due to insufficient data.
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Adverse event rates were 23% for HIFU and 7% for cryoablation, indicating a statistically significant difference in safety profiles.
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Both HIFU and cryoablation are effective minimally invasive treatments for breast fibroadenomas, with cryoablation potentially offering better outcomes.
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The study highlights the need for more high-quality comparative research to better inform clinical decisions regarding these treatment options.

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