Clinical Application of Phage Immunoprecipitation Sequencing to Diagnose Enterovirus D68 as the Underlying Etiology in a Case of Guillain-Barré Syndrome - Takeaways - MDSpire

Clinical Application of Phage Immunoprecipitation Sequencing to Diagnose Enterovirus D68 as the Underlying Etiology in a Case of Guillain-Barré Syndrome

  • By

  • Fang Fang Li

  • Alison Faber

  • Jessica M Caleta

  • David M Goldfarb

  • Inna Sekirov

  • Natalie A Prystajecky

  • Jocelyn A Srigley

  • Ram Mishaal

  • Agatha N Jassem

  • August 31, 2024

  • 0 min

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  • 1

    Guillain-Barré syndrome (GBS) is an acute peripheral neuropathy often linked to prior infections, with enterovirus D68 identified as a potential trigger.

  • 2

    Phage immunoprecipitation sequencing (PhIP-Seq) was utilized to detect antibodies against enterovirus D in cerebrospinal fluid, aiding GBS diagnosis.

  • 3

    A case study involved a 6-year-old girl who developed GBS symptoms following a confirmed enterovirus D68 respiratory infection.

  • 4

    GBS can lead to severe complications, including respiratory failure and cranial nerve involvement, necessitating intensive medical care.

  • 5

    The study highlights the importance of advanced serological techniques in diagnosing GBS when traditional pathogen detection methods fail.

Original Source(s)

Clinical Application of Phage Immunoprecipitation Sequencing to Diagnose Enterovirus D68 as the Underlying Etiology in a Case of Guillain-Barré Syndrome

  • by Fang Fang Li, Alison Faber, Jessica M Caleta, David M Goldfarb, Inna Sekirov, Natalie A Prystajecky, Jocelyn A Srigley, Ram Mishaal, Agatha N Jassem

  • August 31, 2024

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