Comparison of the protective effect of human respiratory syncytial virus Pre-F protein combined with different adjuvants in BALB/c mice - Takeaways - MDSpire

Evaluation of the Protective Efficacy of Human Respiratory Syncytial Virus Pre-F Protein with Various Adjuvants in BALB/c Mouse Models

  • By

  • Mengxuan Chu

  • Liang Du

  • Hongqiao Hu

  • Lei Cao

  • Li Zhang

  • Naiying Mao

  • Zhen Zhu

  • Yan Zhang

  • Hai Li

  • July 20, 2026

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  • 1

    Human respiratory syncytial virus (HRSV) poses a significant health risk, particularly to infants and the elderly.

  • 2

    The study evaluated the protective efficacy of HRSV prefusion protein (Pre-F) with various adjuvants in BALB/c mice.

  • 3

    Mice immunized with Pre-F+BFA03 showed the highest neutralizing antibody titers and the lowest lung viral loads.

  • 4

    The Pre-F+AlOH group exhibited the most severe lung damage and highest viral load compared to other groups.

  • 5

    Pre-F protein combined with AlOH+CpG or BFA03 adjuvants provided similar protective effects, superior to AlOH alone.

Original Source(s)

Comparison of the protective effect of human respiratory syncytial virus Pre-F protein combined with different adjuvants in BALB/c mice

  • by Mengxuan Chu, Liang Du, Hongqiao Hu, Lei Cao, Li Zhang, Naiying Mao, Zhen Zhu, Yan Zhang, Hai Li

  • July 20, 2026

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