Exploring potential associations between blood metabolites and cirrhosis risk: a Mendelian randomization and LC–MS/MS analysis

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This study investigates the causal relationship between blood metabolites and cirrhosis using Mendelian randomization and targeted metabolomics.
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The MR analysis identified 11 metabolites associated with increased cirrhosis risk and 3 metabolites linked to its prevention.
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Higher levels of genetically predicted glutamine degradants were associated with a lower risk of cirrhosis (OR = 0.877, p = 0.022).
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Pathway analysis indicated that arginine biosynthesis, proline metabolism, and nitrogen metabolism may be involved in cirrhosis-related metabolic alterations.
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LC–MS/MS analysis revealed lower glutamate and glutathione levels in cirrhosis patients compared to healthy controls, suggesting altered glutamine metabolism.

Frontiers In Medicine

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