Ablative stereotactic MR-guided radiotherapy for >10 cm solid pseudopapillary tumor of the pancreas with liver oligometastases: a case report and literature review

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Solid pseudopapillary tumors (SPTs) are rare pancreatic malignancies with favorable outcomes when resectable but limited options for unresectable cases.
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Magnetic resonance-guided radiotherapy (MRgRT) allows for safe dose escalation in treating anatomically challenging tumors like large SPTs.
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The case study reports a 63-year-old female with a 10 cm pancreatic SPT and liver oligometastases treated successfully with dose-escalated MRgRT.
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The patient tolerated all radiotherapy courses well, achieving a favorable response and remaining asymptomatic nearly 36 months post-treatment.
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This case adds evidence that MRgRT may improve treatment outcomes for complex abdominal tumors compared to traditional CT-guided radiotherapy.

Frontiers In Oncology

by Robert A. Herrera, Nikolai Strusberg-Fernandez, Eyub Y. Akdemir, Fernando De Zarraga, Horacio Asbun, James McCulloch, Nema Bassiri, Michael D. Chuong
May 4, 2026

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