Exercise rejuvenates the “muscle-heart” crosstalk: skeletal muscle-derived exosomal miRNAs in cardiac aging - Takeaways - MDSpire

Exercise rejuvenates the “muscle-heart” crosstalk: skeletal muscle-derived exosomal miRNAs in cardiac aging

  • By

  • Ruibin Jing

  • Xue Pang

  • Xiaona Zhu

  • Sibao Huang

  • Xing Gao

  • July 13, 2026

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  • 1

    Sarcopenia and age-related heart failure create a significant global health challenge, leading to sarcopenic cardiomyopathy.

  • 2

    Skeletal muscle acts as an endocrine organ, releasing factors that influence cardiac health, especially during aging.

  • 3

    Extracellular vesicles (EVs) from skeletal muscle play a dual role in cardiac aging, acting as both harmful and protective agents.

  • 4

    Regular exercise enhances the release of protective EVs enriched with cardioprotective microRNAs, reversing myocardial damage.

  • 5

    This review aims to clarify the muscle-heart vesicular axis and its implications for developing novel therapeutic strategies.

Original Source(s)

Exercise rejuvenates the “muscle-heart” crosstalk: skeletal muscle-derived exosomal miRNAs in cardiac aging

  • by Ruibin Jing, Xue Pang, Xiaona Zhu, Sibao Huang, Xing Gao

  • July 13, 2026

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