Circular RNA circNUP214 serves as a microRNA-31 sponge to promote the progression of myasthenia gravis through NFAT5 - Takeaways - MDSpire

Circular RNA circNUP214 serves as a microRNA-31 sponge to promote the progression of myasthenia gravis through NFAT5

  • By

  • Fanfan Xu

  • Xiaotong Kong

  • Shanshan Peng

  • Lifang Li

  • Wenqi Tian

  • Hanlu Cai

  • Yichen Li

  • Ying Li

  • Jingyan Niu

  • Nan Zhang

  • Huixue Zhang

  • Lihua Wang

  • July 9, 2026

  • 0 min

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  • 1

    Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness due to autoantibodies targeting the neuromuscular junction.

  • 2

    CircNUP214 expression is significantly elevated in PBMCs and CD4+ T cells from MG patients compared to healthy controls.

  • 3

    CircNUP214 promotes CD4+ T cell proliferation and upregulates NFAT5 expression by sponging miR-31.

  • 4

    The study confirms the interaction between circNUP214 and miR-31, establishing a regulatory axis involving NFAT5.

  • 5

    The findings suggest that the circNUP214/miR-31/NFAT5 axis may contribute to CD4+ T cell proliferation in MG.

Original Source(s)

Circular RNA circNUP214 serves as a microRNA-31 sponge to promote the progression of myasthenia gravis through NFAT5

  • by Fanfan Xu, Xiaotong Kong, Shanshan Peng, Lifang Li, Wenqi Tian, Hanlu Cai, Yichen Li, Ying Li, Jingyan Niu, Nan Zhang, Huixue Zhang, Lihua Wang

  • July 9, 2026

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