Substance P-Related Neuro-Immune-Epithelial Interactions May Play a Role in Mucosal Damage in Gastro-Oesophageal Reflux Disease - Takeaways - MDSpire

Substance P-Related Neuro-Immune-Epithelial Interactions May Play a Role in Mucosal Damage in Gastro-Oesophageal Reflux Disease

  • By

  • Tom Leech

  • Philip Woodland

  • Madusha Peiris

  • April 27, 2026

  • 0 min

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  • 1

    Substance P (SP) is released into the oesophageal mucosa during acid perfusion, impacting neuro-immune-epithelial interactions.

  • 2

    NK1R expression is significantly higher in the oesophageal mucosa of non-erosive reflux disease (NERD) and erosive reflux disease (ERD) patients.

  • 3

    Exposure to SP activates inflammatory pathways in oesophageal epithelial cells, leading to the release of cytokines IL-6 and IL-8.

  • 4

    The density of MRGPRX2+ mast cells is significantly increased in NERD and ERD mucosa compared to healthy controls.

  • 5

    Close proximity between SP+ nerve fibres and mast cells suggests a potential pathological role in gastro-oesophageal reflux disease.

Original Source(s)

Substance P-Related Neuro-Immune-Epithelial Interactions May Play a Role in Mucosal Damage in Gastro-Oesophageal Reflux Disease

  • by Tom Leech, Philip Woodland, Madusha Peiris

  • April 27, 2026

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