Bioinformatics-driven insights: rapamycin-mediated CaMK2D inhibition alleviates intestinal ischemia-reperfusion injury

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Intestinal ischemia-reperfusion injury significantly increases morbidity and mortality, necessitating effective therapeutic strategies.
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CaMK2D hyperactivation contributes to intestinal epithelial apoptosis and barrier dysfunction during ischemia-reperfusion injury.
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Rapamycin treatment reduces CaMK2D expression and phosphorylation, improving intestinal integrity and inflammatory responses.
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Bioinformatic analysis revealed a CaMK2D-centric regulatory module enriched in calcium signaling pathways.
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This study highlights rapamycin's potential as a pharmacological approach to mitigate intestinal ischemia-reperfusion injury.

Frontiers In Immunology

by Ruxiang Sheng, Yanqiu Liang, Huihong Zhang, Yonghe Lai, Haiyun Hong, Dingbang Huang, Dezhao Liu
May 1, 2026

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