Transplant indications, guidelines and recommendations: Caveat Emptor - Takeaways - MDSpire

Transplant indications, guidelines and recommendations: Caveat Emptor

  • By

  • Robert Peter Gale

  • Giovanni Barosi

  • October 28, 2021

  • 0 min

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  • 1

    High-quality clinical practice guidelines are essential for clinical decision-making in hematopoietic cell transplantation.

  • 2

    The ASCTC guidelines have been criticized for their quality and the lack of robust evidence supporting many transplant recommendations.

  • 3

    Indications, guidelines, recommendations, and standard-of-care are distinct concepts that are often misused in transplant literature.

  • 4

    Only a small percentage of ASCTC's standard-of-care recommendations are supported by randomized controlled trials.

  • 5

    The fundamental limitation of transplant guidelines is the scarcity of high-quality data from randomized controlled trials.

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